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Erythropoietin Stimulating Agents – Procrit Prior Authorization Criteria - Medicare Part D
Medicare Drug Policy
Version Date: 01/01/2025

Note: Procrit also subject to Medicare B vs. D review

Prior Authorization Criteria for Approval

Procrit will be approved when ALL of the following are met:

  1. The requested medication is being prescribed for ONE of the following: 
    1. To reduce the possibility of allogeneic blood transfusion in a surgery patient AND the patient’s hemoglobin level is greater than 10 g/dL but less than or equal to 13 g/dL OR 
    2. Anemia due to myelosuppressive chemotherapy for a non-myeloid malignancy AND ALL of the following:
      1. The patient’s hemoglobin level is less than 10 g/dL for patients initiating Erythropoietin Stimulating Agent (ESA) therapy OR less than 12 g/dL for patients stabilized on therapy (measured within the previous 4 weeks) AND
      2. The patient is being concurrently treated with chemotherapy with or without radiation (there must be a minimum of 2 additional months of planned chemotherapy) AND
      3. The intent of chemotherapy is non-curative OR
    3. Anemia associated with chronic kidney disease in a patient NOT on dialysis AND ALL of the following:
      1. The patient’s hemoglobin level is less than 10 g/dL for patients initiating ESA therapy OR 11 g/dL or less for patients stabilized on therapy (measured within the previous 4 weeks) AND
      2. The rate of hemoglobin decline indicates the likelihood of requiring a RBC transfusion AND
      3. The intent of therapy is to reduce the risk of alloimmunization and/or other RBC transfusion related risks OR 
    4. Anemia due to myelodysplastic syndrome AND the patient’s hemoglobin level is less than 12 g/dL for patients initiating ESA therapy OR less than or equal to 12 g/dL for patients stabilized on therapy (measured within the previous 4 weeks) OR 
    5. Anemia resulting from zidovudine treatment of HIV infection AND the patient’s hemoglobin level is less than 12 g/dL for patients initiating ESA therapy OR less than or equal to 12 g/dL for patients stabilized on therapy (measured within the previous 4 weeks) OR
    6. Another indication that is supported in CMS approved compendia for the requested medication AND the patient’s hemoglobin level is less than 12 g/dL for patients initiating ESA therapy OR less than or equal to 12 g/dL for patients stabilized on therapy (measured within the previous 4 weeks) AND 
  2. The patient’s transferrin saturation and serum ferritin have been evaluated AND 
  3. The patient does NOT have any FDA labeled contraindications to the requested medication

Length of Approval:

IndicationLength of Approval
Allogenic blood transfusion in surgery patients1 month
Myelosuppressive chemotherapy, non-myeloid malignancy6 months
Chronic kidney disease NOT ON DIALYSIS12 months
Myelodysplastic syndrome12 months
Zidovudine treatment for HIV12 months
All other diagnoses12 months
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