Skip to main content
Shop Plans Learn more about our coverage options including health, Medicare, dental and vision options for you, your family or your employees. Get Started Individual & Family Medicare Employer Vision Dental International Travel Find Care FAQ Blog Members Stay on top of your health care with helpful member resources. Members Home Medicare Health Dental Vision Find Care Member Knowledge Center Member Forms Medicare Forms Library Make a Payment Federal Employees Student Blue Healthy Blue Providers Access tools, policies and the latest information to help you care for our members. Providers Home Network Participation Networks & Programs Claims, Appeals & Inquiries Prior Authorization Services & CPT codes Prescription Drug Search Forms and Documents Policies, Guidelines & Codes Provider News Provider FAQ Contact Us Employers Learn about our coverage options for small and large employers, and access tools and resources for your group. Employers Home Shop Employer Plans Employer Portal Support Member Forms & Resources Find Care Blog Agents Access the tools you need: rate quotes, applications, forms, the latest industry news, marketing materials and more. Agents Home Agent Services Check Eligibility Find Care Member Forms & Resources Medicare Forms Library
Contact Us
Log In
I am ... Please select A member A provider An employer An agent
Log in to Agent Services
Log in to Employer Services Register for Employer Services I'm registered but need portal access
Username Forgot username? Continue to Log In Register for the member portal Need help? Learn how to log in.
Log in to Blue e Register for Blue e Log in to Dental Blue
Back
Blue Cross NC Medicare Part B: New step therapy and prior authorization requirements, effective April 6, 2026 April 06, 2026 Pharmacy

Effective April 6, 2026, Blue Cross and Blue Shield of North Carolina (Blue Cross NC) will expand Medicare Part B step therapy and prior authorization requirements for select Part B medications. Prior authorization will address medical necessity, while step therapy focuses on the use of safe, lower-cost alternatives.

Please note:

  • Any prior requirements already in place for these medications will continue to apply
  • Step therapy program requirements will only apply to members new to these medications; current users will not be impacted

Medications affected

The following Medicare Part B medications* will require prior authorization or step therapy beginning April 6, 2026:

HCPCS code

Medication name

Requirement

Effective date

Q5157

Osenvelt

Prior authorization

04/06/2026

Q5157

Stoboclo

Prior authorization

04/06/2026

Q5136

Wyost

Prior authorization

04/06/2026

J0897

Xgeva

Step therapy

04/06/2026

J0897

Prolia

Step therapy

04/06/2026

Q5158

Bomyntra

Step therapy

04/06/2026

Q5158

Conexxence

Step therapy

04/06/2026

J3490, J3590

Xtrenbo

Step therapy

04/06/2026

J3490, J3590

Enoby

Step therapy

04/06/2026

Q5162

Bilprevda

Prior authorization

04/06/2026

Q5162

Bildyos

Prior authorization

04/06/2026

Q5161

Aukelso

Step therapy

04/06/2026

Q5161

Bosaya

Step therapy

04/06/2026

Q5159

Ospomyv

Step therapy

04/06/2026

Q5159

Xbryk

Step therapy

04/06/2026

J9256

Imaavy

Step therapy

04/06/2026

*This list may not be comprehensive.

Beginning April 6, 2026, step therapy requirements will apply to members new to Xgeva and Prolia (HCPCS code: J0897). These medications are being specifically identified due to high utilization. Members currently using these medications will not be impacted.

View Medicare Part B step therapy and prior authorizations for more information.

Provider action required

For dates of service on or after April 6, 2026, providers must submit required clinical information to Blue Cross NC when prescribing impacted medications.

For faster service, providers can submit requests to Blue Cross NC through our free online prior authorization tools:

  • Medical drug requests should be submitted electronically only through CoverMyMeds (CMM)
  • Pharmacy drug requests can be submitted through your preferred method: CMM or MHK, accessed through Blue e

If you do not have online access, you can submit requests via fax or phone to the numbers listed at the top of the drug-specific fax form.

Important billing and coverage reminders

Please be aware that if prior plan approval of these medications is not given by Blue Cross NC, the service(s) may not be covered under the member’s Medicare Advantage plan, and the provider may be responsible for the entire cost of the drug and associated service(s). Providers cannot bill members for services when prior plan approval is required but was not obtained by the provider before services were rendered.

Additionally, if the member changes Blue Cross NC Medicare Advantage plans, you may need to certify they have met our medical necessity criteria under the new policy for the medication(s) in question.

Additional resources

Providers can find the newest drug list, criteria, and more information about our utilization programs at the following links:

You can also find specific criteria and fax forms on Blue e or through CMM.

Questions?

Please call our Provider Blue Medicare line at 888-296-9790 for assistance.

About Us Newsroom Blog Member Forms Transparency in Coverage Find Care Rights & Responsibilities Policies & Best Practices Privacy Policy Website User Agreement Fraud & Abuse Technical Information Contact Us Locations Careers

Blue Cross and Blue Shield of North Carolina does not discriminate on the basis of race, color, national origin, sex, age or disability in its health programs and activities. Learn more about our non-discrimination policy and no-cost services available to you.

Information in other languages: Español   中文   Tiếng Việt   한국어   Français   العَرَبِيَّة   Hmoob   ру́сский   Tagalog   ગુજરાતી   ភាសាខ្មែរ   Deutsch   हिन्दी   ລາວ   日本語

© 2026 Blue Cross and Blue Shield of North Carolina. ®, SM Marks of the Blue Cross and Blue Shield Association, an association of independent Blue Cross and Blue Shield plans. All other marks and names are property of their respective owners. Blue Cross and Blue Shield of North Carolina is an independent licensee of the Blue Cross and Blue Shield Association.